Department of Neurobiology, Physiology, and Behavior - NPB

Undergraduate Advising:
EXB 530.752.2292
NPB 530.752.9696

Main Phone: 530.752.0203
Main Fax: 530.752.5582

Mailing Address:
Dept. of NPB
UC Davis
1 Shields Avenue
Davis, CA 95616


1978 - Chair, Animal Physiology


Professor Emeritus
dewoolley (at) ucdavis (dot) edu

B.S., Biology, Bowling Green University, magna cum laude in 3 years
M.S., Physiology, Ohio State University
Ph.D., Physiology, University of California, Berkeley

Personal Data:
3 children and 5 grandchildren.

Teaching Interests:
Neurophysiological basis of neurotoxicology; neuroendocrinology; comparative neurointegrative mechanisms; neurobiology of addictive drugs.

Research Interests:
Effects of stress and neurotoxicants on peripheral benzodiazepine receptors in the brain.
Plasticity in limbic evoked potentials produced by drugs and toxicants and its relation to behavior in the freely behaving rat. Pharmacological modulation of brain estrogen receptors. (August 2001 - Scenes around the laboratory)

Professional Positions:
NSF Postdoctoral Fellow, Lecturer, Assistant Research Physiologist, Department of Physiology, University of California, Berkeley; Lecturer, Department of Physiology, University of California, School of Medicine, San Francisco.

Assistant Professor, Associate Professor and Professor of Physiology and Environmental Toxicology, in sequence, Departments of Animal Physiology (now Neurobiology, Physiology and Behavior) and Environmental Toxicology, University of California, Davis; Chairperson, Department of Animal Physiology, 1978-1982.

Selected Professional Activities:
Member, NIH Toxicology Study Section, July 1974-July 1978; Member, Peer Review Committee, National Library of Medicine Toxicology Data Bank, 1974-1979; Member, International Advisory Board for journal NeuroToxicology, 1979-1988; Former Member, Editorial Board for Journal of Toxicology and Environmental Health and for Toxicology and Applied Pharmacology; Member, EPA Health Effects Research Review Panel, 1980-1984; Member, National Scientific Advisory Council for NIEHS, Fall 1986 through Fall 1990.

Member, College of A&ES Personnel Committee, 1977-1978; Chair, Animal Physiology, 1978-1982; Member, Committee on Privilege and Tenure (three 3-year terms, each during different decades); Committee on Committees (Acting Chair when Charlie Nash gone); Executive Committee, Academic Senate 1993-1995; Emeriti Committee, Academic Senate, 2000 - . Member, Internal Advisory Committee and Executive Committee, Center for Environmental Health Sciences, F. Matsumura, P.I., 1993 - present.

Selected Publications:
(Selected from 94 publications, one book review, two co-edited monograms and 79 abstracts.)

Woolley, D.E. and Z.A. Hasan. Long-lasting proconvulsant and anticonvulsant changes in limbic evoked field potentials are produced by the GABA-antagonist heptachlor. Poster presentation, Society for Neuroscience, 2001. Manuscript in preparation.

Garcia, E.F., B.K. So, V.T. Hoang, and D.E. Woolley. (2001) First increased and then decreased peripheral benzodiazepine receptor (PBR) binding in brain follow both electroshock- and heptachlor-induced seizures. The Toxicologist 60 (No.1): abs. 1167, p. 245.

Woolley, D.E., E. Garcia, L. Drummer and K. Dai. (2000) Lindane per os inhibits its own absorption; PK 11195 exacerbates and devazepide antagonizes this. The Toxicologist 54 (No. 1): abs. # 1250, p. 266.

Hasan, Z.A., M.M. Hasan, K. Karim and D.E.Woolley. (1999) Effects of propofol and thiopentone on pilocarpine-induced  limbic seizures in the rat. Biomedical Letters 60: 55-63.

Hasan, Z.A. and D.E. Woolley. (1999) The short-acting anesthetic propofol produces biphasic effects - depression and withdrawal rebound overshoot - on some but not all limbic evoked potentials. Brain Res. 818:51-64.

Hasan, Z.A., D.E. Woolley and D.W. Gietzen. (1998) Responses to amino acid deficiency and replenishment recorded in the anterior piriform cortex. Nutritional Neuroscience (1998), 1:373-381.

Woolley, D.E. (1995) Organochlorine insecticides: neurotoxicity and mechanisms of action. In: L. Chang and R. Dyer, editors. Handbook of Neurotoxicology. Marcel Dekker, New York, pp. 475-510.

Woolley, D.E. (1994) Differential effects of benzodiazepines, including diazepam, clonazepam, Ro 5-4864 and devazepide, on lindane-induced toxicity. Proc. West. Pharmacol. Soc., 37: 131-134.

Hasan, Z.A. and D.E. Woolley. (1994) Comparison of the effects of propofol and thiopental on the pattern of maximal electroshock seizures in the rat. Pharmacol. & Toxicol. 74: 50-53.

Woolley, D.E., W.G. Hope, M.A. Thompson-Reece, D.W. Gietzen and S. Conway. (1994) Dopaminergic stimulation of estrogen receptor binding in vivo: a reexamination. Rec. Prog. Horm. Res. 49: 383-392.

Hasan, Z., L. Zimmer, H.L. Drummer, T. Tubbs and D.E. Woolley. (1993) Comparison of the effects of propofol, diazepam and pentobarbital on hippocampal potentials evoked by prepyriform stimulation in the freely behaving rat. Proc. West. Pharmacol. Soc. 36: 283-287.

Matteucci, M.J., D.H. Wisner, R.A. Gunther and Dorothy E. Woolley. (1993) Effects of hypertonic and isotonic fluid infusion on the flash evoked potential in rats: hemorrhage, resuscitation, and hypernatremia. J. Trauma 34 (1): 1-7.

Dai, K.-S. and D.E. Woolley. (1991) Ro 5-4864, like picrotoxin, enhances EPSP-spike coupling in the freely behaving rat. Brain Res. Bull. 27 (1): 13-17.

Drummer, H.L. and D.E. Woolley. (1991) Toxicokinetics of Ro 5-4864, lindane and picrotoxin compared. Pharmacol. Biochem. Behav. 38: 235-242.

Dai, K.-S., D.E. Woolley, Z.A. Hasan and H.L. Drummer. (1991) Changes in limbic evoked potentials produced by the atypical benzodiazepine Ro 5-4864. Proc. West. Pharmacol. Soc. 34: 485-488 .

Griffith, J.A. and D.E. Woolley. (1989) "Central" and "peripheral" benzodiazepines and kinetics of lindane-induced toxicity. Pharmacol. Biochem. Behav. 32: 367-376.

Woolley, D.E. and J.A. Griffith. (1989) Kinetics and thresholds of several indices of lindane-induced toxicity. Pharmacol. Biochem. Behav. 33: 787-792 .

Woolley, D.E. and L. Zimmer. (1986) Effects and proposed mechanisms of action of lindane in mammals: unsolved problems. In: J.M. Clark and F. Matsumura, editors. Membrane Receptors and Enzymes as Targets of Insecticidal Actions. Plenum Press, N.Y., N.Y. pp. 1-31.

Gietzen, D. and D.E. Woolley. (1986) Sex differences in [3H]-estradiol binding in brain and pituitary after acute dopaminergic treatment: in vivo studies in the rat. Neuroendocrinology 42: 334-343.

Zimmer, L., D.E. Woolley and L. Chang. (1985) Does phenobarbital protect against trimethyltin-induced neuropathology of limbic structures? Life Sciences 36: 851-858.

Woolley, D.E., L. Zimmer, D. Dodge and K Swanson. (1985) Effects of lindane-type insecticides in mammals: unsolved problems NeuroToxicology 6 (2): 165-192.

Woolley, D.E. (1985) Application of neurophysiological techniques to toxicological problems: an overview. Fund. Appl. Toxicol. 5: 1-8.

Kawamoto, J.C., V.K. Vijayan and D.E. Woolley. (1984) Morphometric effects of exposure to lead during the preweaning period on the hippocampal formation of aging rats. Neurobiology of Aging 5: 297-307.

Woolley, D.E., L. Zimmer, Z. Hasan and K. Swanson. (1984) Do some insecticides and heavy metals produce long-term potentiation in the limbic system? In: T. Narahashi, editor. Cellular and Molecular Neurotoxicology. Raven Press, New York, pp. 45-69.

Woolley, D.E. (1984) A perspective of lead poisoning in antiquity and the present. NeuroToxicology 5 (3): 353-362.

Gietzen, D.W. and D.E. Woolley. (1984) Acetylcholinesterase activity in the brain of rat pups and dams after exposure to lead via the maternal water supply. NeuroToxicology 5 (3): 235-246.

Hasan, Z., L. Zimmer and D.E. Woolley. (1984) Time course of the effects of trimethyltin on limbic evoked potentials and distribution of tin in blood and brain in the rat. NeuroToxicology 5 (2): 217-244.

Campbell-Kawamoto, J., S. Overmann, D.E. Woolley and V. Vijayan. (1984) Morphometric effects of preweaning lead exposure on the hippocampal formation of adult rats. NeuroToxicology 5 (3): 125-148.

Gietzen, D.W., W.G. Hope and D.E. Woolley. (1983) Dopaminergic agonists increase [3H]estradiol binding in hypothalamus of female rats, but not of males. Life Sciences 33: 2221-2228.

Thompson, M., D.E. Woolley, D. Gietzen and S. Conway. (1983) Catecholamine synthesis inhibitors acutely modulate [3H]estradiol binding by specific brain areas and pituitary in ovariectomized rats. Endocrinology 113: 855-865.

Woolley, D.E. and N.D. Woolley-Efigenio. (1983) Specific dietary components alter the toxicity of lead exposure in the postweaning rat. Proc. West. Pharmacol. Soc. 26: 179-183.

Swanson, K.J. and D.E. Woolley. (1982) Comparison of the neurotoxic effects of chlordecone and dieldrin in the rat. Neurotoxicology 3: 81-102.

Overmann, S.R., L. Zimmer and D.E. Woolley. (1982) Electroconvulsive shock elicits wet-dog shakes and facewashing in preweaning rats. Physiol. Behav. 29: 1025-1037.

Campbell, J.B., D.E. Woolley, V.K. Vijayan and S.R. Overmann. (1982) Morphometric effects of postnatal lead exposure on hippocampal development of the 15-day-old rat. Develop. Brain Res. 3: 595-612.

Woolley, D.E. (1982) Neurotoxicity of DDT and possible mechanisms of action. In: Prasad, K.N. and A. Vernadakis, eds. Mechanisms of Actions of Neurotoxic Substances. Raven Press, New York. pp. 95-141.

Chandler, D. B., D. E. Woolley, and S. R. Overmann. (1982) Amygdaloid kindling progressively increases posttetanic potentiation and long-term potentiation of responses evoked in the hippocampus and dentate gyrus. Proc. West. Pharmacol. Soc. 25:443-447.

Overmann, S.R., L. Zimmer and D.E. Woolley. (1981) Motor development, tissue weights and seizure susceptibility in perinatally lead-exposed rats. Neurotoxicology 2: 725-742.

Overmann, S.R., D.E. Woolley and R.L. Bornschein. (1980) Hippocampal potentials evoked by stimulation of olfactory basal forebrain and lateral septum in the rat. Brain Res. Bull. 5: 437-449.

Fox, D.A., S.R. Overmann and D.E. Woolley. (1979) Neurobehavioral ontogeny of neonatally lead-exposed rats. II. Maximal electroshock seizures in developing and adult rats. Neurotoxicology 1: 149-170.

Overmann, S.R., D.A. Fox and D.E. Woolley. (1979) Neurobehavioral ontogeny of neonatally lead-exposed rats. I. Reflex development and somatic indices. Neurotoxicology 1: 125-147.

Woolley, D.E., J.R. Chernobieff and L. Reiter. (1979) Effects of parathion on the mammalian nervous system. In: Narahashi, T., ed. Neurotoxicology of Insecticides and Pheromones. Plenum Press, New York. pp. 155-182.

Woolley, D.E. and L. Reiter. (1978) Dissociation between time course of acetylcholinesterase inhibition and neurophysiological effects of parathion administration in the rat and monkey. In: Otto, D., ed. Multidisciplinary Perspectives in Event-Related Brain Potential Research. EPA Publication No. 600/9-77-043.

Woolley, D.E. (1976) Some aspects of the neurophysiological basis of insecticide action. Fed. Proc. 35: 2610-2617.

Ogren, L. and D.E. Woolley. (1976) Increase in 3H-estradiol binding in brain and pituitary with time after gonadectomy in adult male and female rats. Neuroendocrinology 22: 259-272.

Ogren, L., M. Vertes and D.E. Woolley. (1976) In vivo nuclear 3H-estradiol binding in brain areas of the rat: Reduction by endogenous and exogenous androgens. Neuroendocrinology 21: 350-365.

Reiter, L.W., G.M. Talens and D.E. Woolley. (1975) Parathion administration in the monkey: Time course of inhibition and recovery of blood cholinesterases and visual discrimination performance. Toxicol. Appl. Pharmacol. 33: 1-13.

Maurer, R. A. and D.E. Woolley. (1975) 3H-Estradiol distribution in female, androgenized female, and male rats at 100 and 200 days of age. Endocrinology 96 (5): 755-765.

Maurer, R. A. and D.E. Woolley. (1974) Demonstration of nuclear 3H-estradiol binding in hypothalamus and amygdala of female, androgenized female, and male rats. Neuroendocrinology 16: 137-147.

Maurer, R. A. and D.E. Woolley. (1974) 3H-Estradiol distribution in normal and androgenized female rats using an improved hypothalamic dissection procedure. Neuroendocrinology 14: 87-94.

Woolley, D. E. (1970) Effects of DDT and of drug-DDT interactions on electroshock seizures in the rat. Toxicology and Applied Pharmacology 16:521-532.

Woolley, D. E. (1970) Effects of DDT on the nervous system of the rat. IN: The Biological Impact of Pesticides in the Environment, Environmental Health Sciences Series No. 1, J. W. Gillett, editor, Oregon State University Press, Corvallis, Oregon, pp. 114-124. Discussion on pp. 142-145.

Henderson, Gary L., and D. E. Woolley. (1970) Mechanisms of neurotoxic action of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (DDT) in immature and adult rats. Journal of Pharmacology and Experimental Therapeutics 175:60-68.

Henderson, Gary L., and D. E. Woolley. (1970) Ontogenesis of drug- induced tremor in the rat. Journal of Pharmacology and Experimental Therapeutics 175:113-120.

Woolley, D. E. (1970) Effects of acute and chronic exposure to DDT and of DDT-drug interactions on experimental seizure responses. Industrial Medicine 39:50-54.

Henderson, Gary L., and D. E. Woolley. (1969) Studies on the relative insensitivity of the immature rat to the neurotoxic effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). Journal of Pharmacology and Experimental Therapeutics 170:173-180.

Woolley, D. E., and B. A. Barron. (1968) Hippocampal responses evoked by stimulation of the prepyriform cortex in the rat. Electroencephalography and Clinical Neurophysiology 24:63-74.

Woolley, D. E., and B. A. Barron. (1968) Effects of DDT on brain electrical activity in awake, unrestrained rats. Toxicology and Applied Pharmacology 12:440-454.

Woolley, D. E., and A. L. Runnells. (1967) Distribution of DDT in brain and spinal cord of the rat. Toxicology and Applied Pharmacology 11:389-395.

Williams, B., D. E. Woolley, and P. Timiras. (1966) Synaptic delay and conduction time in brain during exposure to simulated high altitudes. Nature 211:889-890.

Woolley, D. E., B. A. Barron, and P. S. Timiras. (1966) Spectral components in prepyriform electrical activity and changes at high altitude. Electroencephalography and Clinical Neurophysiology 20:175-180.

Woolley, D.E. and P.S. Timiras. (1962) The gonad-brain relationship: Effects of female sex hormones on electroshock convulsions in the rat. Endocrinology 70: 196-209.

Woolley, D. E., P. S. Timiras, M. R. Rosenzweig, D. Krech, and E. L. Bennett. (1961) Sex and strain differences in electroshock convulsions of the rat. Nature 190 (4775):515-516.

Published Scientific Papers
Presentation at Meetings
Wapakoneta Daily News, 2007

2007, with former classmate Neil Armstrong

1999, In Laboratory

Dr. Zuheir Hasen, 1996
Chair, Dept. of Physiology,
Jordan University of Science and Technology,
Irbid, Jordan.

Drs. Lou Zimmer (left) and Steve Overmann in 1979
researching away in C2A!!

Dr. Gary Henderson, Ph.D, in 1970, shown here in 1980.
Currently, Professor of Medical Pharmacology & Toxicology, UCD.
(Photo: Jim West)

Questions or Comments? | Last Updated: August 10, 2012.
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