Department of Neurobiology, Physiology, and Behavior - NPB

Latest Research Publication Covers

JBC Cover

Clustered localization pattern of the Kv2.1 potassium channel in cultured rat hippocampal neurons. The image shows the clustered localization of the Kv2.1 channel (green), the synaptic marker PSD95 (red), the axon initial segment marker ankyrin-G (magenta), and the dendritic marker MAP2 (blue). In this issue, Cerda and Trimmer, pages 28738–28748, show that CDK5 modulates the phosphorylation and localization of the Kv2.1 potassium channel. Oscar Cerda and James S. Trimmer.

JCN Cover

Varicosities in dendrites and axon of a rat retinal ganglion cell, and in neurites projecting through the field from other cells. Retina was immersed in formaldehyde after inducing green fluorescent protein expression. The authors (Stradleigh et al.) show that formaldehyde-based fixatives induce varicosity formation in retinal ganglion cells, and that this is precluded by sucrose, but not (as in other central neurons) by glutamate receptor antagonists, tetrodotoxin, Ca2+ exclusion, or temperature shifts. TW Stradleigh, KP Greenberg, GJ Partida, A Pham, and AT Ishida.

Molecular Biology of the Cell Cover

Image: Jie Zhu and Alex Mogilner, University of California, Davis; Anton Burakov, Moscow State University, Moscow, Russia; and Vladimir Rodionov, University of Connecticut Health Center.

Faculty and Research

Research Publications:

Stradleigh TW, Greenberg KP, Partida GJ, Pham A, Ishida AT (2015). Moniliform deformation of retinal ganglion cells by formaldehyde-based fixatives. Journal of Comparative Neurology J Comp Neuro 523: 545-564.

Sun Y, Do H, Gao J, Zhao R, Zhao M, Mogilner A. 2013. Keratocyte Fragments and Cells Utilize Competing Pathways to Move in Opposite Directions in an Electric Field. Cur Biol. 23: 569-574.

Allen GM, Mogilner A, Theriot JA. 2013. Electrophoresis of Cellular Membrane Components Creates the Directional Cue Guiding Keratocyte Galvanotaxis. Curr Biol. 23: 560-568.

Miller LM
. 2013. Shaken, not stirred: emergence of neural selectivity in a "cocktail party". Neuron 77(5):806-9.

Akiyama T, Tominaga M, Davoodi A, Nagamine M, Blansit K, Horwitz A, Carstens MI, Carstens E. 2013. Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors. J Neurophysiol. 109(3):742-8.

Allard J, Mogilner A. 2013. Traveling waves in actin dynamics and cell motility.Curr Opin Cell Biol. 25(1):107-15.

Da Costa S, van der Zwaag W, Miller LM, Clarke S, Saenz M. 2013. Tuning in to sound: frequency-selective attentional filter in human primary auditory cortex. J Neurosci. 33(5):1858-63.

Oh WC, Hill TC, Zito K. 2013. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci USA. 110(4):E305-12.
Hill TC, Zito K. 2013.
LTP-induced long-term stabilization of individual nascent dendritic spines. J Neurosci. 33(2):678-86.

Churchland AK, Ditterich J. 2012. New advances in understanding decisions among multiple alternatives. Curr Opin Neurobiol. 22(6):920-6.

Iorga A, Dewey S, Partow-Navid R, Gomes AV, Eghbali M. 2012. Pregnancy is associated with decreased cardiac proteasome activity and oxidative stress in mice. PLoS One. 7(11):e48601.

Pölkki M, Kortet R, Hedrick A, Rantala MJ. 2012. Dominance is not always an honest signal of male quality, but females may be able to detect the dishonesty. Biol Lett. 9(1):20121002.

Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. 2012. Cardiomyopathies: classification, clinical characterization, and functional phenotypes. Biochem Res Int. 2012:870942.

Zhu J, Mogilner A. 2012. Mesoscopic model of actin-based propulsion.PLoS Comput Biol. 8(11):e1002764.

Pinto JR, Gomes AV, Jones MA, Liang J, Nguyen S, Miller T, Parvatiyar MS, Potter JD. 2012. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 287(44):37362-70.

Bishop CW, London S, Miller LM. 2012. Neural time course of visually enhanced echo suppression. J Neurophysiol. 108(7):1869-83.

Lewis CJ, Becker JJ, Manis AD, Hamilton JS, Horowitz JM, Horwitz BA. 2012. Neuroprotection supports signal processing in the hippocampus of Syrian hamsters, a facultative hibernator. Neurosci Lett. 520(1):20-5.

Hamilton AM, Oh WC, Vega-Ramirez H, Stein IS, Hell JW, Patrick GN, Zito K. 2012. Activity-dependent growth of new dendritic spines is regulated by the proteasome. Neuron. 74(6):1023-30.

Weidner WJ, Bradbury CA, Le SP, Wallace SR. 2012. Regional pulmonary blood flow in the lung of the chicken. Poult Sci. 91(6):1441-3.

Sekizawa S, Horowitz JM, Horwitz BA, Chen CY. 2012. Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 198(4):267-82.

Carey HV, Martin SL, Horwitz BA, Yan L, Bailey SM, Podrabsky J, Storz JF, Ortiz RM, Wong RP, Lathrop DA. 2012. Elucidating nature's solutions to heart, lung, and blood diseases and sleep disorders. Circ Res. 110(7):915-21.

Ogata G, Stradleigh TW, Partida GJ, Ishida AT. 2012. Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. Journal of Comparative Neurology 520: 4032-4049.

Bollimunta A, Totten D, Ditterich J. 2012. Neural Dynamics of Choice: Single-Trial Analysis of Decision-Related Activity in Parietal Cortex. J. Neuroscience. 32(37):12684 –12701.

Klein AH, Sawyer CM, Takechi K, Davoodi A, Ivanov MA, Carstens MI, Carstens E. 2012. Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons. Neuroscience. 219:234-42.

Spradley JM, Davoodi A, Gee LB, Carstens MI, Carstens E. 2012. Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin. Neuropharmacology. 63(4):743-9.

Shinomori, K, Werner JS. 2012. Aging of human short-wave cone pathways. Proceedings of the National Academy of Sciences USA. 109(33):13422-13427.

Spradley JM, Davoodi A, Carstens MI, Carstens E. 2012. Effects of acute stressors on itch- and pain-related behaviors in rats. Pain. 153(9):1890-7.

Akiyama T, Carstens MI, Ikoma A, Cevikbas F, Steinhoff M, Carstens E. 2012. Mouse model of touch-evoked itch (alloknesis). J Invest Dermatol. 132(7):1886-91.

Manning CF, Bundros AM, Trimmer JS. 2012. Benefits and Pitfalls of Secondary Antibodies: Why Choosing The Right Secondary is of Primary Importance. PLoS ONE 7: e38313.

Menegola M, Clark E, Trimmer JS. 2012. The Importance of Immunohistochemical Analyses in Evaluating the Phenotype of Kv Channel Knockout Mice. Epilepsia. 53:142-149.

Akiyama T, Tominaga M, Carstens MI, Carstens EE. 2012. Site-dependent and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching. Eur J Neurosci. 36(3):2311-6.

Spradley JM, Davoodi A, Carstens MI, Carstens E. 2012. Opioid Modulation of Facial Itch- and Pain-related Responses and Grooming Behavior in Rats. Acta Derm Venereol. doi: 10.2340/00015555-1364.

Mogilner A
. Allard J, Wollman R. 2012. Cell polarity: Quantitative modeling as a tool in cell biology. Science. 336:175-179.

Bodine SC
, Baar K. 2012. Analysis of skeletal muscle hypertrophy in models of increased loading. Methods Mol Biol. 798:213-29.

Bollimunta A, Ditterich J. 2012. Local computation of decision-relevant net sensory evidence in parietal cortex. Cereb Cortex. 22:903-917.

Vinogradova T, Paul R, Grimaldi AD, Loncarek J, Miller PM, Yampolsky D, Magidson V, Khodjakov A, Mogilner A, Kaverina I. 2012. Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not maintenance. Mol. Biol. Cell. 23:820-833.

Philp A, Hargreaves M, Baar K. 2012. More than a store: Regulatory roles for glycogen in skeletal muscle adaptation to exercise. Am J Physiol Endocrinol Metab. 302(11):E1343-51.

Silkworth WT, Nardi IK, Paul R, Mogilner A, Cimini D. 2012. Timing of centrosome separation is important for accurate chromosome segregation. Mol. Biol. Cell. 23:401-411.

Lacayo CI, Soneral PAG, Zhu J, Tsuchida MA, Footer MJ, Soo FS, Lu Y, Xia Y, Mogilner A, Theriot JA. 2012. Choosing Orientation: Influence of Cargo Geometry and ActA Polarization on Actin Tails. Mol. Biol. Cell. 23:614-629.

Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD. 2012. A cell autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoide exposure. Am J Physiol Endocrinol Metab. 302(10):E1210-20.

Ramenofsky M, Cornelius JM, Helm B. 2012. Physiological and behavioural responses of migrants to environmental cues, J. Ornithology. 153(1):181-191.

Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, Degorordo A, Murdoch J, Willis MS, Patterson C, Tanskersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. 2012. A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting. Am J Respir Crit Care Med. 185(8):825-34.

Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH. 2012. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 148(3):421-33.

Paxton JZ, Hagerty P, Andrick JJ, Baar K. 2012. Optimizing an intermittent stretch paradigm using ERK1/2 phosphorylation results in increased collagen synthesis in engineered ligaments. Tissue Eng Part A. 18(3-4):277-84.

Partida GJ, Stradleigh TW, Ogata G, Godzdanker I, Ishida AT. 2012. Thy1 associates with the cation channel subunit HCN4 in adult rat retina. Investigative Ophthalmology and Visual Science. 53(3):1696-703.

Questions or Comments? | Last Updated: November 22, 2013.
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