Skeletal Muscle Physiology Recruitment Seminar
Tyler Kirby, PhD is a Post-doctoral Fellow with Cornell University. The overarching theme of my research is to understand the molecular mechanisms that cause skeletal muscle weakness and wasting in physiological aging and disease states. I am using mammalian in vitro systems and mouse models to address how mutations in the LMNA gene, which encodes for the nuclear-envelope protein lamin A/C, lead to myonuclear defects and muscular dystrophy. In addition, I aim to understand the biochemical and biophysical mechanisms responsible for the changes in nuclear structure and organization found in aged skeletal muscle, and how these changes contribute to the reduced functionality of aged myofibers.