Skeletal Muscle Physiology Recruitment Seminar
Lucas Smith, PhD is a Research Associate with the University of Pennsylvania. Fibrosis or scaring occurs in many tissues in response to injury and is especially disruptive in mechanical tissues such as skeletal muscle as it directly compromises function. However, the muscle mechanics is not determined by the amount of fibrotic tissue, but instead the way the fibrotic material is organized. Disorganization and inability to remodel fibrotic scar also compromise the ability of resident stem cells to regenerate fibrotic muscle, presenting hurdles that must be addressed in pursuit of successful regenerative medicine.